![]() ![]() This can lead to little or no hypocretin present within the cerebrospinal fluid (CSF), especially in the cases with cataplexy. These neurons play a crucial role in the regulation of both appetite and sleep cycles ( 5). A suspected cause is the autoimmune response towards hypocretin producing neurons within the hypothalamus. First-degree relatives of narcoleptics have greater chance of developing narcolepsy than the general population. The cause of narcolepsy is still unknown, but both environmental and genetic factors are involved in the pathogenesis. In contrast, excessive daytime sleepiness is most often the first presenting symptom and is found in all patients with narcolepsy ( 4). Although cataplexy is pathognomonic for narcolepsy and is present in approximately 70% of narcolepsy patients its absence increases the challenge of diagnosis. However, the presence of all these symptoms is only seen in about 15% of patients ( 3). The main manifestations of narcolepsy are: excessive daytime sleepiness, cataplexy, disturbed nighttime sleep, hypnagogic/hypnopompic hallucinations and sleep paralysis. It can also be found throughout the world in all races and ethnic groups albeit with differing penetration ( 2). The prevalence of the condition is equal in both men and women with those affected normally diagnosed between the ages of 20 and 40. It is estimated that it affects 0.05% of the general population that is almost 31,000 people within the UK ( 1). Narcolepsy is a rare, chronic disorder that affects the regulation of the sleep wake cycle. Keywords: Narcolepsy multiple sleep latency test (MSLT) sleep onset rapid eye movement (SOREM) sleep diagnostics Our study shows that only a few patients may benefit from a 5 th nap opportunity which also led to increase of the mean sleep latency at the expense of extra time, cost, labour and increased patient anxiety. 6.7 after inclusion of the 5 th nap.Ĭonclusions: The 5 th nap is not often performed within the MSLT studies. In 53% of cases the mean sleep latency increased due to 5 th nap inclusion the mean sleep latency of the first four naps was 5.6 vs. Here a 5 th nap allowed diagnostic criteria of mean sleep latency 2 SOREMPS to be met. In 16% of cases a diagnosis of narcolepsy was given directly due to the inclusion of the 5 th nap on the MSLT. Results: Fifty-three patients had a 5 th nap performed out of 378 MSLT studies. Methods: Data was retrospectively collected from the Sleep Disorders Centre of a Tertiary Hospital on patients that had a 5 th nap during their MSLT from the 08 th November 2011 to 12 th November 2014. Policy of Dealing with Allegations of Research Misconductīackground: This is the first study that aimed to look specifically at the utility of the 5 th nap in the multiple sleep latency test (MSLT), a test used to assist in the diagnosis of narcolepsy.Policy of Screening for Plagiarism Process. ![]()
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